吴汉夔

 副教授

15137238927

wuhankui222@126.com

学习及工作经历

2016.6-2016.12 美国加州大学圣地亚哥分校 国家留学基金委公派访问学者

2010.1-2011.4   美国密西西比大学 博士后

2009.7-  安阳师范学院,历任讲师、副教授

2008.9-2009.7    南京大学 博士后

2007.1-2007.4    乌兹别克斯坦科学院植物化学研究所 中科院公派访问学者

2003.9-2008.7    中国科学院大学  博士

1999.9-2003.6    中国药科大学 本科

研究方向

      主要研究天然药物化学,研究方向有:(1)天然倍半萜、二萜类化学成分的分离、结构鉴定及抗老年痴呆活性成分研究;(2)天然化合物的生物转化、化学衍生化及生物活性研究; (3)特境微生物次级代谢产物分离鉴定及生物活性研究。

      已主持国家自然科学基金项目2项,省部级科研项目2项;参与国家自然科学基金项目2项,NIH项目一项;已发表SCI论文30余篇;获得国家发明专利6项,转让1项;主编教材一部(《生物技术制药发展及其分离方法研究》),参编“十三五”规划《天然药物化学》教材一部(“萜类和挥发油”一章)。任河南省亚临界萃取工程技术中心科学顾问。

主持/参与科研项目

  1. 国家自然科学基金青年基金:三种益母草属植物中二萜类化合物及其精神活性作用机制研究 (经费:25万;校内另匹配25万,编号:21302004),主持,已结项。

  2. 国家自然科学基金-河南人才培养联合基金:毛菊苣中萜类成分的亚临界流体萃取、化学转化及其降血糖活性研究(经费:30万;校内另匹配30万,编号:U1304825),主持,已结项。

  3. 国家自然科学基金项目:基于β-分泌酶靶点的天然产物Asperterpene A的全合成及其构效关系研究(经费:20.1万;编号:81703353,2018/1-2020/12),在研,第一参与。

  4. 国家自然科学基金项目-河南联合基金:用于食管癌早期诊断的新型F-18标记的靶向EGFR的小分子放射药物研究(经费:50万;编号:U1804188,2019/01-2021/12),在研, 第二参与。

  5. 国家科技支撑计划项目子课题:棉子蛋白深加工与综合开发利用研究及产品开发(经费:10万;编号:2012BAD36B01-02),主持,已结项。

  6. 教育部第46批留学回国人员科研启动基金:毛菊苣萜类成分的生物转化及其降血糖功能研究(经费:3万;校内另匹配1.5万,教外司留[2013]第693号)。主持,已结项。

  7. 中国博士后科学基金(第44批):烟曲霉文丙衍生物的合成及活性研究 (经费:3万;编号:20080441044)。主持,已结项。

  8. 美国健康研究院项目:精神活性植物的化学和生物学研究,(NIH,经费:14万美元;编号:R03DA023491)。参与,已结项。



部分论文/授权专利如下:


  1. Hankui Wu*,  Sensheng Wang,  Zhiyong Xu,  Shanshan Sun,  Haijuan Liu,  Jinjin Wang, Yan E;, Yanyan Lv, Xuelin Dong, Gang Li*, Liping Zhang, Yunfeng Shi*. Isoleojaponin, a new halimane diterpene isolated from Leonurus japonicusMolecules  (2015), 20 (1): 839-845.

  2. Hankui Wu, Jun Li, Frank R. Fronczek, Daneel Ferreira, Charles L. Burandt Jr, Vincent Setola, Bryan L. Roth, and Jordan K. Zjawiony*. Labdane diterpenoids from Leonotis leonurusPhytochemistry (2013), 91: 229-235.

  3. Hankui Wu, Frank R. Fronczek, Daneel Ferreira, Charles L. Burandt, and Jordan K. Zjawiony*. Labdane diterpenoids from Leonorus sibiricusJournal of Natural Products (2011), 74 (4): 831-836.

  4. Hankui Wu, Zhen Su, Yi Yang, Hang Ba and Haji Akber Aisa*. Isolation of three sesquiterpene lactones from the roots of  Cichorium glandulosumBoiss. et Huet. by high-speed counter-current chromatography. Journal of Chromatography A (2007),1176 (1-2): 217-222.

  5. Gang Li*,  Suling Yang,  Bingjie Lv,  Qingqing Han,  Xingxing Ma,  Kai Sun,  Zhiyong Wang,  Feng Zhao,  Yunhe Lv  and  Hankui Wu*. Metal-free methylation of a pyridine N-oxide C–H bond by using peroxides. Organic & Biomolecular Chemistry (2015),13: 11184-11188. [通讯作者]

  6. Gang Li*, Chunqi Jia, Kai Sun, Yunhe Lv, Feng Zhao, Kexiao Zhou  and  Hankui Wu*. Copper(II)-catalyzed electrophilic amination of quinoline N-oxides with O-benzoyl hydroxylamines.Organic & Biomolecular Chemistry(2015),13: 3207-3210.  [通讯作者]

  7. Shi, Yunfeng; Wang, Zhiyong; Weng, Xiaofang; Zhou, Linzhu; Yuan, Baiqing; Deng, Jiming; Yang, Hailan; Wu, Hankui*; Du, Weimin; Du, Jimin; Tong, Gangsheng; Zhu, Xinyuan. Preparation of Highly Fluorescent and pH Responsive CdTe Quantum Dots Within Dynamic Covalent Hyperbranched Polymers and Their In Vitro Application as Fluorescence Probe. Science of Advanced Materials(2015), 7(4) : 615-622. [通讯作者]

  8. Hankui Wu, Frank R. Fronczek, Charles L. Burandt, Jordan K. Zjawiony*. Antileishmanial germacranolides from Calea zacatechichi.Planta Medica (2011), 77:749 – 753. 

  9. H Wu, S Wang, R Liu, H Liu, E Yan, J Wang, Z Xu, Y Lv , S Sun.  Furanic diterpenes from Leonurus japonicus.Planta Medica (2015), 81: PC14.

  10. WU Han-Kui, MAO Yan-Jun, SUN Shan-Shan, XU Zhi-Yong, MA Ya,CAO Jin-Xia, QI He,WU Zhi-Fu,LI Gang,YANG Wei-Hua. Leojaponic acids A and B, two new homologous terpenoids isolated fromLeonurus japonicus. Chinese Journal of Natural Medicines (2016), 14(4): 303-307. 

  11. WU Han-Kui, SUN Ting, ZHAO Feng, ZHANG Li-Ping, LI Gang, ZHANG Jie.New diterpenoids from Leonurus japonicus and their acetylcholinesterase inhibitory activity. Chinese Journal of Natural Medicines (2017,) 15:(11):860-864.

  12. Hankui Wu, Zhen Su, Xuelei Xin, Haji Akber Aisa*. Two new sesquiterpene lactones and a triterpene glycoside from Cichorium glandulosum.Helvetica Chimica Acta (2010), 93 (3): 414 – 421. 

  13. Hankui Wu, Sensheng Wang, Haijuan Liu, Yan E, Yan Li, Ruijin Liu, Jinjin Wang, Zhiyong Xu, Yanyan Lv, Shanshan Sun, Gang Li, Yunfeng Shi. Two new diterpenoids from Leonurus japonicus. Revista Brasileira de Farmacognosia (2015), 25 (2):180-182.

  14. Hankui Wu*, Zhiyong Xu, Ya Ma, He Qi, Jinxia Cao, Gang Li, Yong Chen; Weihua Yang*. Rapid separation of gossypol from cottonseeds by a solid-phase synthetic method. Journal of the Korean Chemical Society(2016), 60 (3) : 215-218.  [EI 收录]

  15. Hankui Wu*, Sensheng Wang, Haijuan Liu, Yan E, Jinjin Wang, Xiangbei Wang, Wenchao Wei, Zhiyong Xu, Shanshan Sun, Yan Li, Ruijin Liu, Gang Li, and Yunfeng Shi*. Diterpenoids from Leonurus japonicus.Journal of the Korean Chemical  Society (2015), 59 (2): 179-182. [EI 收录]

  16. H. K. Wu, X. L. Xin, Z. Su, and H. A. Aisa*. 2-Isopropyl-6-methylpyrimidin- 4(3H)-one and taraxasterol from the stems ofCichorium glandulosum. Chemistry of Natural Compounds (2011), 47 (4), 664 – 666.

  17. Kai Sun, Yunhe Lv, Zhonghong Zhu, Yongqing Jiang, Jiejie Qi, Hankui WuZhiguo Zhang. A convenient access to β-iodo sulfone by the iodine-mediated iodosulfonylation of alkenes. RSC Advances (2015),5: 50701-50704. [ SCI三区]

  18. Kai Sun, Yunhe Lv, Zhonghong Zhu, Liping Zhang,Hankui Wu,  Lin Liu, Yongqing Jiang, Beibei Xiao  and  Xin Wang. Oxidative C–S bond cleavage reaction of DMSO for C–N and C–C bond formation: new Mannich-type reaction forβ-amino ketones.  RSC Advances (2015),5: 3094-3097. [ SCI三区]

  19. Gang Li, Chunqi Jia, Qingliang Chen, Kai Sun, Feng Zhao, Hankui Wu, Zhiyong Wang, Yunhe Lv, Xiaolan Chen. Copper(I)-Catalyzed Dehydrogenative Amidation of Arenes Using Air as the Oxidant.Advanced Synthesis & Catalysis(2015), 357: 1311–1315. [ SCI一区]

  20. Li Gang, Wu Hankui, Wang Zhiyong, and Wang Xianli. One-pot three- component Mannich-type reaction catalyzed by trifluoromethanesulfonic acid in water.Kinetics and Catalysis (2011), 52 (1): 89-93.  [ SCI四区]

  21. Zhen Su, Hankui Wu, Fei He, Slukhan, Usmanova; Aisa, Haji Akber. New guaipyridine sesquiterpene alkaloids from Artemisia rupestrisL. Helvetica Chimica Acta (2010), 93 (1):33-38. [ SCI四区]

  22. Zhen Su, Hankui Wu, Yi Yang, Haji Akber Aisa, Slukhan Usmanova, Aripova Salimakhon. Preparative isolation of guaipyridine sesquiterpene alkaloid from Artemisia rupestrisL. flowers using high-speed counter-current chromatography. Journal of Separation Science (2008), 31 (12): 2161 – 2166.  [ SCI 三区]

  23. Yi Yang, Dongyu Gu, Hankui Wu, Haji Akber Aisa, Tianyou Zhang,Yoichiro Ito. Application of Preparative High- Speed Countercurrent chromatography for Separation of Elatine from Delphinium shawurense.Journal of Liquid Chromatography & Related Technologies (2008), 31 (19): 3012 – 3019. [ SCI 四区]

  24. Fu Xiao Pu, Wu Tao, Abdurahim Miriban, Su Zhen, Hou Xue Ling, Aisa Haji Akber, Hankui Wu. New spermidine alkaloids from Capparis spinosaroots.Phytochemistry Letters (2008), 1: 59 – 62.  [ SCI 四区]

  25. Jun Li, Christina M. Coleman, Hankui Wu, Charles L. Burandt Jr., Daneel Ferreira, Jordan K. Zjawiony*. Triterpenoids and flavonoids from Cecropia schreberiana Miq. (Urticaceae). Biochemical Systematics and Ecology(2013), 48: 96-99. [ SCI 四区]

  26. (专利)谭仁祥, 徐强, 孙洋, 吴汉夔, 戈惠明, 龚方苑, 罗琼, 郭文洁, 苯基苄胺类化合物及其应用, 2012.08.08, 中国, CN201210081607.8

  27. (专利)信学雷,阿吉艾克拜尔·艾萨,阿布力米提·伊力,吴汉夔,瘤果黑种草籽油的药物用途,2008.02.27,中国,CN200710147492.7

  28. (专利)阿吉艾克拜尔·艾萨,吴汉夔, 信学雷, 阿不力米提·伊力, 巴杭,菊苣籽有效部位及其制备方法和用途,2008.04.30,中国,CN200710180028.8

  29. (专利)李刚,杨素玲,吴汉夔,何其戈,马星星,一种间位烷基苯胺的制备方法,2017.12.05,中国,CN201610736314.7

  30. (专利)李刚,杨素玲,王志勇,吴汉夔,何其戈,韩晴晴,马星星,一种2-芳基-2-恶唑啉的制备方法,2015.10.28,中国,CN201510301648.7

  31. (专利)李刚,杨素玲,吴汉夔,孙凯,吕允贺,一种脱氢偶联制备芳基胺的方法,2015.06.10,中国 CN201410684382.4 













































































































































































































































































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